Presentation
Marine is a study engineer in the team of Mickaël Ménager.
She started working in September 2012 at Curie Institute as an assistant engineer in the team of Alain Nicolas "Recombination and Genetic Instability". She helped a doctoral student to study the mechanisms of meiotic recombination in yeast for a year. Then she worked for four years at Cochin Institute as a study engineer in the "Functional pharmacology and physiopathology of membrane receptors" team of Ralf Jockers. Her first project was to study the interaction between GPR50 and Nogo-A, a neuronal growth inhibitor. Then she worked on a project on Alzheimer's disease by studying the aggregation of Tau and Abeta proteins.
Since September 2017, Marine works under the direction of Mickaël Ménager on the understanding of the molecular mechanisms in the inflammatory response and the production of interferon. She brings her technical expertise on the TSPAN7 and CLOCK projects in collaboration with a postdoctoral fellow (Brieuc Pérot) and a doctoral student (Victor Garcia). She is also working on the protein HIF1A, a regulator of the metabolic switch in order to study its impact on the inflammatory response.
She helped set up the emerging Single Cell technology of 10X Genomics within the institute and is now the reference person for the preparation of the various libraries (scRNA-seq, scATAC-seq, CITE-seq, Spatial Transcriptomic) for the team and their various collaborators. Thanks to this technique, she works on auto-inflammatory diseases in order to study them at the transcriptomic level and better characterize them.
Resources & publications
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Journal (source)Cell Death Discov
Kremen1-induced cell death is regulated by homo- and heterodimerization.
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Journal (source)Curr. Opin. Neurobiol.
Cortical developmental death: selected to survive or fated to die.
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Journal (source)Evodevo
Neuronal fate specification by the Dbx1 transcription factor is linked to the...
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Journal (source)Curr. Biol.
Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Con...
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Journal (source)PLoS ONE
Dbx1-expressing cells are necessary for the survival of the mammalian anterio...
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Journal (source)PLoS Biol.
A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of...
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Journal (source)Cell Death Differ.
Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.
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Journal (source)bioRxiv
Functional characterization of RELN missense mutations involved in recessive ...
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Journal (source)Development
The multiple facets of Cajal-Retzius neurons.
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Journal (source)Development
Single-cell transcriptomics of the early developing mouse cerebral cortex dis...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)Curr Opin Neurobiol
Cajal-retzius cells: Recent advances in identity and function
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Journal (source)J Comp Neurol
Diversity within olfactory sensory derivatives revealed by the contribution o...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)J Clin Invest
De novo monoallelic Reelin missense variants act in a dominant-negative manne...
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Journal (source)J Clin Invest
De novo monoallelic Reelin missense variants cause dominant neuronal migratio...
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Journal (source)Development
Differential contribution of P73+ Cajal-Retzius cells and Reelin to cortical ...