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Isabelle Andre is a research director at INSERM and leads the research Human Lymphohematopoiesis laboratory at Imagine Institute.
Her main research focuses on the development of the human hematopoietic immune system, and cell therapy pre-clinical studies for inherited and acquired disease of the hematopoietic system. The research group she leads studies not only how to succeed hematopoietic stem cell transplantation in humans but also the differentiation of mouse and human stem cells towards lymphocyte lineages. She has identified key steps in the production of T cells, key players of immunity generated throughout the life of an individual within the thymus. This work led to the development of an artificial thymus, which will be tested in a clinical trial to reduce the immune deficiency period after bone marrow transplantation. Her team also identified new genes involved in severe forms of inherited immune deficiencies in children and demonstrated genotoxicity of anti-viral drugs, such as AZT, used to prevent transmission of HIV during pregnancy.
She is involved in several clinical trials that are based on the use of ex vivo gene modified hematopoietic stem cells to treat patients with inherited disorders. She is the author or co-author of several patents and of about 60 publications in peer-reviewed journals and was awarded with several national and European grants.
Resources & publications
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Journal (source)Cell Death Discov
Kremen1-induced cell death is regulated by homo- and heterodimerization.
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Journal (source)Curr. Opin. Neurobiol.
Cortical developmental death: selected to survive or fated to die.
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Journal (source)Evodevo
Neuronal fate specification by the Dbx1 transcription factor is linked to the...
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Journal (source)Curr. Biol.
Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Con...
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Journal (source)PLoS ONE
Dbx1-expressing cells are necessary for the survival of the mammalian anterio...
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Journal (source)PLoS Biol.
A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of...
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Journal (source)Cell Death Differ.
Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.
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Journal (source)bioRxiv
Functional characterization of RELN missense mutations involved in recessive ...
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Journal (source)Development
The multiple facets of Cajal-Retzius neurons.
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Journal (source)Development
Single-cell transcriptomics of the early developing mouse cerebral cortex dis...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)Curr Opin Neurobiol
Cajal-retzius cells: Recent advances in identity and function
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Journal (source)J Comp Neurol
Diversity within olfactory sensory derivatives revealed by the contribution o...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)J Clin Invest
De novo monoallelic Reelin missense variants act in a dominant-negative manne...
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Journal (source)J Clin Invest
De novo monoallelic Reelin missense variants cause dominant neuronal migratio...
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Journal (source)Development
Differential contribution of P73+ Cajal-Retzius cells and Reelin to cortical ...