Publications and ressources

LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Alain Fischer

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A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Alain Fischer, Mathieu Kurowska

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Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice.

Geneviève de Saint Basile, Fernando Sepulveda

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Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Mathieu Kurowska, Alain Fischer

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Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex.

Gaël Ménasché, Mathieu Kurowska, Alain Fischer, Geneviève de Saint Basile

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Rab44 regulates murine mast cell–driven anaphylaxis through kinesin-1–dependent secretory granule translocation

Cyril Longe, Mathieu Kurowska, Pierre David, Valère Desmeure, Alain Fischer, Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché

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