As the leading European center for research, care and education on genetic diseases, Imagine’s goal is to change the lives of families affected by genetic diseases. To achieve this goal, Imagine focuses on four major areas: research, innovative care, education, and promotion.

Institute’s founders, this circle begins with the patient and finishes by curing the patient or at least relieving their suffering. Imagine brings together all the skills and expertise necessary to accelerate research, develop innovative care, and to generate synergies and conditions to drive innovation in one building.

 

Understanding the mechanisms of genetic diseases

To cure a genetic disease, the disease must first be identified, which happens in three key steps:

  • First, the gene(s) responsible must be identified, for which the patient cohorts have to be analyzed perfectly.
  • Then, the mutations must be characterized so that we can understand how they disrupt models of biological experimental systems in order to learn how to correct them.
  • This data must then be quickly translated into a diagnosis and clinical research begun.

These three steps are at the heart of the Imagine Institute’s research. To accelerate research, Imagine works with multi-disciplinary teams from Inserm and the University of Paris using a cross-sectoral, cross-disciplinary and translational approach.

This unique approach is a success factor for major scientific advances. Our team is united under the same roof: 1000 researchers, engineers and technicians, 24 research teams, 4 partner labs at Necker-Enfants Malades hospital AP-HP, 15 core facilities and 25 reference centers for rare diseases have combined their talents in aid of one cause: fighting genetic diseases.

Since the Institute’s founding, doctors and researchers have:

  • Identified more than 250 genes, improving both diagnostic capabilities and the lives of many families,
  • Developed more than 32 gene panels allowing for more than 3,000 diseases to be clinically diagnosed,
  • Performed more than 25,000 DNA sequences,
  • Collected data from 680,000 patients, 5.6 million documents and 50 million pieces of structured data in a translational research data warehouse on rare diseases in order to facilitate advances and discoveries relating to these pathologies.

 

 

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