Presentation
Full Professor in Developmental Neuropsychology, Faculty of Medicine, University of Paris - Paris Descartes, and senior Member of the Institut Universitaire de France (IUF), Affiliated to Imagine Institute (Endocrinological Pediatric), and to Research Institute in Public Health (IReSP) ; Clinical Neuropsychologist at Necker-Enfants-Malades Hospital, AP-HP.5, Paris.
Leader of the research team NTDA «Neurodevelopment and learning disabilities »in Inserm Unit 1178-1018-CESP.
Area of expertises focus on the field of the neuro-developmental knowledges on children, from neonate to adolescent, from normal to pathology, with a transactional clinical assessment (on neuromotor, neuropsychological and psychopathological investigations), based on a fine semiology with new neuro-developmental standardized assessments and on environmental factors in a way to understand conditions and processes of developmental trajectories in which appear functioning and dysfunctioning.
The aims being first to understand the underlying cerebral mechanism, the nature and the origin of an eventual disorder with the identification of homogeneous neurodevelopmental profiles in order to enhance the knowledge from a physiological or pathological/endophenotyping point of view, on nosography, specific markers and involved factors, phenotyping characterization and genotyping/phenotyping correlations.
Secondly, to contribute to the preventive interventions and strategies of remediation.
Resources & publications
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Journal (source)Cell Death Discov
Kremen1-induced cell death is regulated by homo- and heterodimerization.
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Journal (source)Curr. Opin. Neurobiol.
Cortical developmental death: selected to survive or fated to die.
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Journal (source)Evodevo
Neuronal fate specification by the Dbx1 transcription factor is linked to the...
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Journal (source)Curr. Biol.
Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Con...
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Journal (source)PLoS ONE
Dbx1-expressing cells are necessary for the survival of the mammalian anterio...
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Journal (source)PLoS Biol.
A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of...
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Journal (source)Cell Death Differ.
Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.
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Journal (source)bioRxiv
Functional characterization of RELN missense mutations involved in recessive ...
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Journal (source)Development
The multiple facets of Cajal-Retzius neurons.
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Journal (source)Development
Single-cell transcriptomics of the early developing mouse cerebral cortex dis...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)Curr Opin Neurobiol
Cajal-retzius cells: Recent advances in identity and function
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Journal (source)J Comp Neurol
Diversity within olfactory sensory derivatives revealed by the contribution o...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)Dev Cell
Repurposing of the multiciliation gene regulatory network in fate specificati...
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Journal (source)J Clin Invest
De novo monoallelic Reelin missense variants act in a dominant-negative manne...
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Journal (source)J Clin Invest
De novo monoallelic Reelin missense variants cause dominant neuronal migratio...
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Journal (source)Development
Differential contribution of P73+ Cajal-Retzius cells and Reelin to cortical ...