Transient perinatal metabolic shifts determine neuronal survival and functional circuit formation

Franck Oury, Alessandra Pierani

Source :

Cell

Pmid / DOI:

37116467

Abstract

Metabolic changes are essential for neurodevelopmental processes. However, little is known about how and when neuronal metabolic remodeling occurs to promote functional circuits. In this issue of Cell, Knaus et al. demonstrate that a temporary perinatal shift in metabolites and lipids is crucial for cortical neurons' survival and wiring.

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